ea0099p396 | Late-Breaking | ECE2024
Gesmundo Iacopo
, Pedrolli Francesca
, Romana Giglioli Francesca
, Bertoldo Alessia
, Gregorc Vanesa
, Sapino Anna
, Righi Luisella
, Cai Renzhi
, Sha Wei
, Giulio Papotti Mauro
, Ghigo Ezio
, V. Schally Andrew
, Ricardi Umberto
, Granata Riccarda
Growth hormone-releasing hormone (GHRH), apart from stimulating GH secretion in the pituitary, exerts many peripheral functions, including stimulation of cell proliferation and survival. In fact, GHRH and GHRH receptors (GHRH-Rs) are expressed in different cancer cell types, where they promote proliferation and survival. Conversely, GHRH antagonists exert antineoplastic activities in several tumors, including lung cancer, one of the leading causes of death by cancer worldwide....